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From Rap Dictionary

'5150' is the police code for an insane person, which is where Van Halen's use came from. This term also named the studio Ed built at his home in CA, and named the album '5150' because it was the first album produced in his new studio. The 5150 amps were named after all of those in general. Eddie is a rock guitar god and a universal musical influence. He played the solo on Michael Jackson's 'Beat It' for free. That's what it has to do with Rap.