C.O.

From Rap Dictionary

noun

C.O.

1.Correctional officer, someone who works in a pen. "C.O. screaming shut the fuck up in the pen" -- 50 Cent (Poor Lil' Rich). "I got C.O.s bringin me filet mignon" - Tony Yayo (Drama Setter ft. Eminem) 2. also stands for Columbus,Ohio 614!!